RAN-Metformin may be available in the countries listed below.
Metformin hydrochloride (a derivative of Metformin) is reported as an ingredient of RAN-Metformin in the following countries:
International Drug Name Search
Codipar 15mg/500mg Effervescent Tablets
Each tablet contains Codeine Phosphate hemihydrate 15mg.and Paracetamol 500mg,
Excipients: Each tablet also contains 389mg of sorbitol and 379 mg of sodium.
For a full list of excipients, see 6.1.
Effervescent Tablet
Bevelled, flat, round, white tablet
For the relief of mild to severe acute pain
Method of administration: Oral
The tablets should be placed in a glass of water and allowed to be dissolved completely. The resulting solution should be drunk immediately.
Adults: The usual dose is two tablets every four hours as required. The total daily dose should not exceed 4 g paracetamol (8 tablets in a day).
Elderly; As for adults, however a reduced dose may be required (see section 4.4)
Paediatric population: Not recommended in children below the age of 18 years (see section 5.1).
Hypersensitivity to either paracetamol or codeine, or any of the excipients of Codipar tablets.
Conditions where morphine and opioids are contraindicated e.g., acute asthma, respiratory depression, acute alcoholism, head injuries, raised intra-cranial pressure and following biliary tract surgery; monoamine oxidase inhibitor therapy, concurrent or within 14 days.
Codipar is also contraindicated in severe liver disease and severe renal impairment. The hazards of overdose could be greater in those with alcoholic liver disease.
Use of codeine containing products is contraindicated in mothers who are breastfeeding unless prescribed by a doctor (see section 4.6).
Care should be observed in administering the product to any patient whose condition may be exacerbated by opioids, including the elderly, who may be sensitive to their central and gastro-intestinal effects, those on concurrent CNS depressant drugs, those with prostatic hypertrophy / urethral stricture and those with inflammatory or obstructive bowel disorders. Care should also be observed if prolonged therapy is contemplated, since side effects are more frequent and may lead to intolerance of the product with regular, long-term use.
Codeine at high doses has the same disadvantages as morphine, including respiratory depression. Drug dependence of the morphine type can be produced by codeine, and the potential for drug abuse with codeine must be considered. Codeine may impair mental or physical abilities required in the performance of potentially hazardous tasks.
Prolonged regular use, except under medical supervision, may lead to physical and psychological dependence (addiction) and result in withdrawal symptoms such as restlessness and irritability, once the drug is stopped.
Care should be taken in patients with liver and kidney disease with suitable dose reductions as appropriate.
Prolonged use except on the doctor's advice may be harmful.
This product should be used only when clearly necessary.
Immediate medical advice should be sought in the event of overdosage, even if the patient feels well, because of the risk of irreversible liver damage.
Patients must be advised not to exceed the recommended dose and not to take other paracetamol containing products concurrently.
The risk-benefit of continued use should be assessed regularly by the prescriber.
Patients must be advised not to take other products containing paracetamol or opiate derivatives when taking Codipar, and to consult their doctor if symptoms persist.
The cough suppressant effect of codeine may be undesirable in patients with some respiratory conditions.
As the effervescent tablet contains 389mg of sorbitol, patients with rare hereditary problems of fructose intolerance should not take this medicine
This medicine contains 379 mg sodium in each tablet. This should be taken into consideration by patients on a controlled sodium (salt) diet.
The hypotensive effects of antihypertensive agents, including diuretics, may be potentiated by codeine.
The CNS depressant action of Codipar may be enhanced by coadministration with any other drug which has a CNS depressant effect (e.g. anxiolytics, hypnotics, antidepressants, antipsychotics and alcohol). Concomitant use of any drug with a CNS depressant action should be avoided. If combined therapy is necessary, the dose of one or both agents should be reduced.
Concomitant administration of Codipar and MAOIs or tricyclic antidepressants may increase the effect of either the antidepressant or codeine.
Concomitant administration of codeine and anticholinergics may cause paralytic ileus.
Concomitant administration of codeine with an anti-diarrhoeal agent increases the risk of severe constipation, and coadministration with an antimuscarinic drug may cause urinary retention.
The absorption of paracetamol may be enhanced by metoclopramide or domperidone, and absorption may be reduced by cholestyramine.
The metabolism of paracetamol is increased in patients taking enzyme-inducing antiepileptics (carbamazepine, phenytoin, phenobarbital, primidone). Isolated reports describe unexpected hepatotoxicity in patients taking phenobarbital, phenytoin, or carbamazepine after taking paracetamol.
The anticoagulant effect of warfarin and other coumarins may be increased by long term regular daily use of paracetamol, with increased risk of bleeding. Occasional doses of paracetamol do not have a significant effect on these anticoagulants.
Dependence of codeine hypoalgesia on morphine formation via CYP2D6 makes this effect liable to interaction with drugs that are inhibitors of CYP2D6. Examples of potent inhibitors of CYP2D6 are quinidine, some selective serotonin reuptake inhibitors, some neuroleptics and ritornavir.
Codeine may delay the absorption of mexilitine
Pregnancy: On the basis of published literature (Danish National Birth Cohort), paracetamol use during any time of pregnancy was associated with a small but statistically significant increased risk of physician-diagnosed asthma or bronchitis among children at 18 months.
Use of codeine during pregnancy may lead to withdrawal symptoms in neonates, and use during labour may cause neonatal respiratory depression.
Codipar is then not recommended during pregnancy.
Lactation: Codeine is excreted in the human milk. The decision to use codeine in nursing women should be based on clinical judgment. If used in such patients, codeine should be administered in the lowest effective dosage for the shortest possible time.
In nursing mothers, who are ultra-rapid metabolisers of codeine, higher than expected serum and breast milk morphine levels can occur. Morphine toxicity in babies can cause excessive somnolence, hypotonia, miosis and difficulty breastfeeding or breathing. In severe cases respiratory depression and death can occur. In severe cases, naloxone may be appropriate to reverse the effects. The lowest effective dose should be used, for the shortest possible time.
Nursing mothers should be informed about carefully monitoring the infant during treatment for any signs and/or symptoms of morphine toxicity such as increased drowsiness or sedation, difficulty breastfeeding, breathing difficulties, miosis and decreased tone, and seeking immediate medical care if such symptoms or signs are noticed. The nursing mother should be informed about monitoring for signs and symptoms of maternal opioid toxicity as well. Should such signs/symptoms be noted in mother or baby, the mother should immediately stop taking all codeine-containing medicines and seek medical advice.
Paracetamol is distributed in human milk, although its concentration is 20% lower than in plasma. For these reasons, Codipar should be avoided during breast-feeding.
Patients should be advised not to drive or operate machinery if Codipar causes dizziness or sedation. Codeine may cause visual disturbances.
Reported adverse reactions seem more prominent in ambulatory than non-ambulatory patients and some of these effects may be alleviated if the patient lies down.
The most commonly (>1/100, <1/10) reported reactions are:
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In clinical use of paracetamol-containing products, blood dyscrasias (including thrombocytopenia and agranulocytosis) are reported rarely (>1/10000, <1/1000).
Also, rarely hypersensitivity including skin rash may occur with paracetamol use. _
The frequencies of the following side effects are not known or cannot be estimated from the data available:
Eye disorders: Miosis
Renal and urinary disorders: Urinary retention
Codeine can cause respiratory depression particularly in overdosage and in patients with compromised respiratory function (see Section 4.9).
Liver damage in association with therapeutic use of paracetamol has been documented; most cases have occurred in conjunction with chronic alcohol abuse.
Regular prolonged use of codeine is known to lead to addiction and symptoms of restlessness and irritability may result when treatment is then stopped.
Codeine
Large doses of codeine produce respiratory depression and hypotension, with circulatory failure and deepening coma. Convulsions may occur from respiratory failure. Blood concentrations of codeine ranged from 1.4 to 5.6 mg/l in eight adults whose deaths were attributed primarily to codeine overdosage.
Primary attention should be given to the re-establishment of adequate respiratory exchange through the provision of a patent airway and the institution of controlled ventilation. Oxygen, intravenous fluids, vasopressors and other supportive measures should be employed as indicated. Opioid antagonists may be employed. Gastric lavage should be considered. Patients should remain under observation, as per hospital guidelines and on a case per case basis.
Paracetamol
Because of its ready availability, paracetamol is often taken in overdosage. Toxicity is likely if more than 150 mg/kg of paracetamol is ingested. The major complication is acute hepatic necrosis, although without treatment fewer than 10% of unselected patients are at risk of severe liver damage (plasma aminotransferase > 1000 mg/l). About 1% develop fulminant hepatic failure which is usually fatal. Renal failure from acute tubular necrosis is a further uncommon complication which may develop in the absence of hepatic failure. There are no specific early manifestations of severe paracetamol poisoning. Consciousness is not impaired except in the occasional unusually severely poisoned patient with metabolic acidosis, and maximum abnormality of liver function tests is delayed for at least 3 days.
Emergency estimation of the plasma paracetamol concentration is therefore necessary to determine the severity of intoxication and the need for specific therapy with N-acetylcysteine (NAC).
Patients who have ingested more than 150 mg/kg should have gastric lavage performed if they present within an hour of ingestion. Activated charcoal may also be given. A plasma paracetamol level will indicate the likelihood of a patient developing high ALT/AST activities (i.e> 1,000 i.u. /L) and must be measured at least 4 hours after ingestion. Plasma levels measured less than 4 hours post-ingestion cannot be interpreted. Patients with a plasma level above the treatment line require N-acetylcysteine (NAC). A paracetamol normogram should be employed to determine treatment levels.
Patients who present to an Accident and Emergency Department more than 8 hours after ingesting a paracetamol overdose are at greater risk of developing hepatic damage. In cases of severe poisoning, hepatic failure may progress to encephalopathy, coma and death.
Blood should be taken for a plasma level, but the NAC infusion should be started as soon as possible if more than 150 mg/kg was taken. The NAC infusion should not be delayed while awaiting the result of the plasma paracetamol level. Administration of the antidote should be stopped if the plasma level is subsequently found to be below the treatment line. General supportive measures must be available.
At the end of the NAC infusion, blood should be taken to check the INR and creatinine concentration. If the investigations are abnormal, a further infusion of NAC (at 16 hour dose), to be continued until recovery or death, should be considered.
In the range of concentrations associated with overdosage, paracetamol may give a false positive result for plasma salicylate in tests based on the direct colour reaction with ferric ions. In the same circumstances it may induce spuriously high results for blood dextrose estimated with the YSI and Yellow Springs Model 23AM dextrose analyzers. Conversely, it may cause falsely low results for dextrose when the dextrose peroxidase/dextrose-6-phosphate dehydrogenase method is used
Liver damage following overdosage is relatively uncommon in young children.
Pharmacotherapeutic group: Anilides, Paracetamol combinations
ATC Code: NO2B E51
Paracetamol is an analgesic which acts peripherally, probably by blocking impulse generation at the bradykinin sensitive chemo-receptors which evoke pain. Paracetamol is a weak, reversible, isoform-nonspecific cyclooxygenase inhibitor at dosages of 1 g daily. The inhibitory effect of paracetamol on cyclooxygenase-1 is limited, and the drug does not inhibit platelet function. Animal studies have indicated that paracetamol strongly inhibits prostaglandin synthetase in the brain (which may account for its antipyretic and analgesic effects) but that it has little effect on peripheral tissue prostaglandins (which are involved in inflammatory reactions).
Codeine is a centrally acting analgesic. Codeine exerts its effect through µ opioid receptors, although codeine has an exceptionally low affinity or these receptors, and its analgesic effect is due to its conversion to morphine. However, its antitussive actions may involve distinct receptors that bind codeine itself.
The conversion of codeine to morphine is effected by the CYP2D6. Well-characterised genetic polymorphism in CYP2D6 lead to the inability to covert codeine to morphine, thus making codeine ineffective as an analgesic for about 10% of the Caucasian population.
The fixed combination of paracetamol and codeine has been shown to be effective in acute nociceptive pain. However, data in chronic pain, cancer pain and neuropathic pain are lacking.
Paracetamol is rapidly and completely absorbed after oral administration, with peak plasma concentrations occurring between 15 min and 2 h after ingestion. Paracetamol is distributed throughout most body tissues, with an apparent volume of distribution of approximately 1 L/kg of body weight. Concentrations in whole blood are up to 20% higher and in breast milk about 20% lower. Paracetamol crosses the placenta. Paracetamol is extensively metabolised in the liver and the total body clearance is about 5 ml/min/1/kg. Some 2-5% of a therapeutic dose of paracetamol is excreted unchanged in the urine.
Codeine is absorbed rapidly following oral administration; peak plasma concentrations occur in about 1 h and the plasma half-life is about 3.5 h. The volume of distribution is approximately 3.6 l/kg. The total body clearance of codeine is approximately 0.85 l/min. Codeine crosses the placenta and is present in the milk of lactating mothers.
Codeine is metabolised in the liver by O-demethylation to form morphine (codeine is in fact a pro-drug to morphine), and other metabolites. After an oral dose, about 86% is excreted in the urine in 24 h as free drug and metabolites, mostly in the form of metabolites. Some of a dose of codeine is excreted in the bile and trace amounts are found in the faeces. Unchanged drug accounts for 6-8% of the dose in urine in 24 h.
The bioavailabilities of paracetamol and codeine, when given as the combination, are similar to those when they are given separately.
There are no findings of relevance to the prescriber other than those already mentioned elsewhere in the SPC.
Sodium Hydrogen carbonate
Sodium carbonate anhydrous
Citric acid anhydrous
Sorbitol Neosorb P60 W
Povidone K30
Sodium Saccharin
Macrogol 6000
Grapefruit flavour
Not applicable
2 years
Do not store above 25°C
Strips of Aluminium / polyethylene foils
Each strip contains 4 tablets individually packed in cardboard containers.of 100 tablets.
The tablets should be placed in a glass of water and allowed to be dissolved completely. The resulting solution should be drunk immediately.
No special requirements for disposal
Goldshield Pharmaceuticals Ltd
NLA Tower 12-16 Addiscombe Road
Croydon CR0 0XT
United Kingdom
PL 12762/0405
16/08/2010
07/02/2011
Class Name: antihistamine (Oral route, Parenteral route, Rectal route)
In the U.S.
In Canada
Available Dosage Forms:
Antihistamines are used to relieve or prevent the symptoms of hay fever and other types of allergy. They work by preventing the effects of a substance called histamine, which is produced by the body. Histamine can cause itching, sneezing, runny nose, and watery eyes. Also, in some persons histamine can close up the bronchial tubes (air passages of the lungs) and make breathing difficult.
Some of the antihistamines are also used to prevent motion sickness, nausea, vomiting, and dizziness. In patients with Parkinson's disease, diphenhydramine may be used to decrease stiffness and tremors. Also, the syrup form of diphenhydramine is used to relieve the cough due to colds or hay fever. In addition, since antihistamines may cause drowsiness as a side effect, some of them may be used to help people go to sleep.
Hydroxyzine is used in the treatment of nervous and emotional conditions to help control anxiety. It can also be used to help control anxiety and produce sleep before surgery.
Some antihistamines are used in the treatment of chronic urticaria, which is a persistent hive-like rash.
Antihistamines may also be used for other conditions as determined by your doctor.
Antihistamine preparations are available both over-the-counter (OTC) and with your doctor's prescription.
Do not give any over-the-counter (OTC) cough and cold medicine to a baby or child under 4 years of age. Using these medicines in very young children might cause serious or possibly life-threatening side effects .
Once a medicine has been approved for marketing for a certain use, experience may show that it is also useful for other medical problems. Although these uses are not included in product labeling, some antihistamines are used in certain patients with the following medical conditions:
Make certain your health care professional knows if you are on a low-sodium, low-sugar, or any other special diet. Most medicines contain more than their active ingredient, and many liquid medicines contain alcohol.
Tell your doctor if you have ever had any unusual or allergic reaction to medicines in this group or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.
Serious side effects, such as convulsions (seizures), are more likely to occur in younger patients and would be of greater risk to infants than to older children or adults. In general, children are more sensitive to the effects of antihistamines. Also, nightmares or unusual excitement, nervousness, restlessness, or irritability may be more likely to occur in children.
Do not give any over-the-counter (OTC) cough and cold medicine to a baby or child under 4 years of age. Using these medicines in very young children might cause serious or possibly life-threatening side effects .
Elderly patients are usually more sensitive to the effects of antihistamines. Confusion; difficult or painful urination; dizziness; drowsiness; feeling faint; or dryness of mouth, nose, or throat may be more likely to occur in elderly patients. Also, nightmares or unusual excitement, nervousness, restlessness, or irritability may be more likely to occur in elderly patients.
Hydroxyzine is not recommended for use in the first months of pregnancy since it has been shown to cause birth defects in animal studies when given in doses many times higher than the usual human dose. Be sure you have discussed this with your doctor.
Desloratadine and fexofenadine have not been studied in pregnant women. However, studies in animals have shown that these medicines cause birth defects or other problems when given in doses higher than the usual human dose. Before taking this medicine, make sure your doctor knows if you are pregnant or if you may become pregnant.
Azatadine, brompheniramine, cetirizine, chlorpheniramine, clemastine, cyproheptadine, dexchlorpheniramine, dimenhydrinate, diphenhydramine, doxylamine, and loratadine have not been studied in pregnant women. However, these medicines have not been shown to cause birth defects or other problems in animal studies.
Small amounts of antihistamines pass into the breast milk. Use is not recommended since babies are more susceptible to the side effects of antihistamines, such as unusual excitement or irritability. Also, since these medicines tend to decrease the secretions of the body, it is possible that the flow of breast milk may be reduced in some patients. It is not known yet whether cetirizine, desloratadine, or loratadine cause these same side effects.
Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking any of these medicines, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.
Using medicines in this class with any of the following medicines is not recommended. Your doctor may decide not to treat you with a medication in this class or change some of the other medicines you take.
Using medicines in this class with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.
Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.
Using medicines in this class with any of the following is usually not recommended, but may be unavoidable in some cases. If used together, your doctor may change the dose or how often you use your medicine, or give you special instructions about the use of food, alcohol, or tobacco.
The presence of other medical problems may affect the use of medicines in this class. Make sure you tell your doctor if you have any other medical problems, especially:
For patients taking this medicine by mouth:
For patients taking dimenhydrinate or diphenhydramine for motion sickness:
For patients using the suppository form of this medicine:
For patients using the injection form of this medicine:
Antihistamines are used to relieve or prevent the symptoms of your medical problem. Take them only as directed. Do not take more of them and do not take them more often than recommended on the label, unless otherwise directed by your doctor. To do so may increase the chance of side effects.
The dose medicines in this class will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of these medicines. If your dose is different, do not change it unless your doctor tells you to do so.
The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.
For use as an antihistamine:
For nausea, vomiting, and vertigo (only dimenhydrinate and diphenhydramine are used for vertigo):
For Parkinson's disease:
For use as a sedative (to help sleep):
For anxiety:
If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.
Keep out of the reach of children.
Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.
Do not keep outdated medicine or medicine no longer needed.
Before you have any skin tests for allergies, tell the doctor in charge that you are taking this medicine. The results of the test may be affected by this medicine.
When taking antihistamines on a regular basis, make sure your doctor knows if you are taking large amounts of aspirin at the same time (as for arthritis or rheumatism). Effects of too much aspirin, such as ringing in the ears, may be covered up by the antihistamine.
Antihistamines will add to the effects of alcohol and other CNS depressants (medicines that slow down the nervous system, possibly causing drowsiness). Some examples of CNS depressants are sedatives, tranquilizers, or sleeping medicine; prescription pain medicine or narcotics; barbiturates; medicine for seizures; muscle relaxants; or anesthetics, including some dental anesthetics. Check with your doctor before taking any of the above while you are using this medicine.
This medicine may cause some people to become drowsy or less alert than they are normally. Even if taken at bedtime, it may cause some people to feel drowsy or less alert on arising. Some antihistamines are more likely to cause drowsiness than others. Drowsiness is less likely with cetirizine, and rare with desloratadine and loratadine. Make sure you know how you react to the antihistamine you are taking before you drive, use machines, or do anything else that could be dangerous if you are not alert.
Antihistamines may cause dryness of the mouth, nose, and throat. Some antihistamines are more likely to cause dryness of the mouth than others . For temporary relief of mouth dryness, use sugarless candy or gum, melt bits of ice in your mouth, or use a saliva substitute. However, if your mouth continues to feel dry for more than 2 weeks, check with your medical doctor or dentist. Continuing dryness of the mouth may increase the chance of dental disease, including tooth decay, gum disease, and fungus infections.
For patients using dimenhydrinate, diphenhydramine, or hydroxyzine:
For patients using diphenhydramine or doxylamine as a sleeping aid:
Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur:
Less common or rare with azatadine, cetirizine, clemastine, cyproheptadine, desloratadine, dexchlorpheniramine, diphenhydramine, or loratadine
Check with your doctor as soon as possible if any of the following side effects occur:
Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.
Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.
The information contained in the Thomson Healthcare (Micromedex) products as delivered by Drugs.com is intended as an educational aid only. It is not intended as medical advice for individual conditions or treatment. It is not a substitute for a medical exam, nor does it replace the need for services provided by medical professionals. Talk to your doctor, nurse or pharmacist before taking any prescription or over the counter drugs (including any herbal medicines or supplements) or following any treatment or regimen. Only your doctor, nurse, or pharmacist can provide you with advice on what is safe and effective for you.
The use of the Thomson Healthcare products is at your sole risk. These products are provided "AS IS" and "as available" for use, without warranties of any kind, either express or implied. Thomson Healthcare and Drugs.com make no representation or warranty as to the accuracy, reliability, timeliness, usefulness or completeness of any of the information contained in the products. Additionally, THOMSON HEALTHCARE MAKES NO REPRESENTATION OR WARRANTIES AS TO THE OPINIONS OR OTHER SERVICE OR DATA YOU MAY ACCESS, DOWNLOAD OR USE AS A RESULT OF USE OF THE THOMSON HEALTHCARE PRODUCTS. ALL IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE OR USE ARE HEREBY EXCLUDED. Thomson Healthcare does not assume any responsibility or risk for your use of the Thomson Healthcare products.
Generic Name: acetaminophen and tramadol (a SEET a MIN o fen and TRAM a dol)
Brand Names: Ultracet
Tramadol is a narcotic-like pain reliever. Acetaminophen is a less potent pain reliever that increases the effects of tramadol.
The combination of acetaminophen and tramadol is used to treat moderate to severe pain.
Acetaminophen and tramadol may also be used for purposes not listed in this medication guide.
alcohol;
tramadol (Ultram) or narcotic pain medicine;
sedatives or tranquilizers (such as Valium);
medicine for depression or anxiety;
medicine for mental illness (such as bipolar disorder, schizophrenia); or
street drugs.
Seizures have occurred in some people taking acetaminophen and tramadol. Your risk of a seizure may be higher if you have any of these conditions:
a history of drug or alcohol addiction;
a history of epilepsy or other seizure disorder;
a history of head injury;
a metabolic disorder;
an infection of your brain or spinal cord, such as meningitis or encephalitis;
if you are also taking an antidepressant, mood stabilizer, or another narcotic pain medicine; or
if you have taken an MAO inhibitor such as isocarboxazid (Marplan), linezolid (Zyvox), phenelzine (Nardil), rasagiline (Azilect), selegiline (Eldepryl, Emsam), or tranylcypromine (Parnate) within the past 14 days.
Talk with your doctor about your individual risk of having a seizure.
To make sure you can safely take acetaminophen and tramadol, tell your doctor if you have any of these other conditions:
kidney disease;
liver disease;
asthma or other breathing disorder;
a stomach disorder; or
a history of depression, mental illness, or suicide attempt.
The maximum amount of acetaminophen and tramadol is 2 tablets per dose, or 8 tablets per day. Acetaminophen and tramadol should not be used for longer than 5 days in a row.
Acetaminophen and tramadol can be taken with or without food, but take it the same way each time.
See also: Acetaminophen and tramadol dosage (in more detail)
Since pain medicine is taken as needed, you may not be on a dosing schedule. If you are taking the medication regularly, take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.
The first signs of an acetaminophen overdose include loss of appetite, nausea, vomiting, stomach pain, sweating, and confusion or weakness. Later symptoms may include pain in your upper stomach, dark urine, and yellowing of your skin or the whites of your eyes.
Overdose symptoms may also include drowsiness, shallow breathing, slow heartbeat, extreme weakness, sweating, cold or clammy skin, feeling light-headed, fainting, seizure, or coma.
seizure (convulsions);
agitation, hallucinations, fever, fast heart rate, overactive reflexes, nausea, vomiting, diarrhea, loss of coordination, fainting;
a red, blistering, peeling skin rash; or
shallow breathing, weak pulse.
Less serious side effects may include:
dizziness, drowsiness, weakness, tired feeling;
stomach pain, constipation, loss of appetite;
dry mouth, blurred vision;
feeling nervous or anxious;
sweating, itching; or
sleep problems (insomnia).
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Usual Adult Dose for Pain:
Short term management of acute pain (5 days or less): 2 tablets every 4 to 6 hours as needed for pain.
Maximum dose: 8 tablets per day.
Usual Geriatric Dose for Pain:
Short term management of acute pain (5 days or less): 2 tablets every 4 to 6 hours as needed for pain.
Maximum dose: 8 tablets per day.
The following drugs can interact with acetaminophen and tramadol. Tell your doctor if you are using any of these:
carbamazepine (Carbatrol, Equetro, Tegretol);
warfarin (Coumadin, Jantoven);
digoxin (Lanoxin, Lanoxicaps);
ketoconazole (Nizoral);
erythromycin (E-Mycin, E.E.S., Ery-Tab);
rifampin (Rifadin, Rimactane, Rifater);
quinidine (Quin-G);
St. John's wort;
sumatriptan (Imitrex, Treximet) and other migraine headache medicines;
an antidepressant such as amitriptyline (Elavil), citalopram (Celexa), desipramine (Norpramin), fluoxetine (Prozac, Sarafem), imipramine (Tofranil), nortriptyline (Pamelor), paroxetine (Paxil), or sertraline (Zoloft); or
drugs to treat high blood pressure or a prostate disorder, such as alfuzosin (Uroxatral), doxazosin (Cardura), prazosin (Minipress), terazosin (Hytrin), tamsulosin (Flomax).
This list is not complete and other drugs may interact with acetaminophen and tramadol. Tell your doctor about all medications you use. This includes prescription, over the counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.
ATF-Long may be available in the countries listed below.
Adenine is reported as an ingredient of ATF-Long in the following countries:
International Drug Name Search
Nitrofurazona Sertex may be available in the countries listed below.
Nitrofural is reported as an ingredient of Nitrofurazona Sertex in the following countries:
International Drug Name Search
Bactiprox may be available in the countries listed below.
Ciprofloxacin hydrochloride (a derivative of Ciprofloxacin) is reported as an ingredient of Bactiprox in the following countries:
International Drug Name Search
Treating acne. It may also be used for other conditions as determined by your doctor.
Avidoxy DK is a kit containing a tetracycline antibiotic, a topical salicylate, and a sunscreen. The tablets work by slowing the growth of bacteria, which allows the body's immune system to destroy the bacteria. The wash works to clean the skin of dirt and oil and helps to remove dead skin cells. The sunscreen helps to prevent sunburn.
Contact your doctor or health care provider right away if any of these apply to you.
Some medical conditions may interact with Avidoxy DK. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:
Some MEDICINES MAY INTERACT with Avidoxy DK. Tell your health care provider if you are taking any other medicines, especially any of the following:
This may not be a complete list of all interactions that may occur. Ask your health care provider if Avidoxy DK may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.
Use Avidoxy DK as directed by your doctor. Check the label on the medicine for exact dosing instructions.
Ask your health care provider any questions you may have about how to use Avidoxy DK.
All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:
Dry, peeling, red, or scaling skin; loss of appetite; mild diarrhea; nausea; sensitivity to sunlight; vomiting.
Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue; unusual hoarseness); bloody stools; dark urine; decreased urination; fever, chills, or sore throat; moderate to severe sunburn; red, swollen, blistered, or peeling skin; severe diarrhea; severe or persistent headache; severe skin irritation; stomach pain or cramps; throat irritation; trouble swallowing; unusual bruising or bleeding; unusual joint pain; vaginal irritation or discharge; vision changes; yellowing of the skin or eyes.
This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.
See also: Avidoxy DK side effects (in more detail)
Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately
Store Avidoxy DK at 77 degrees F (25 degrees C). Brief storage at temperatures between 59 and 86 degrees F (15 and 30 degrees C) is permitted. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Avidoxy DK out of the reach of children and away from pets.
This information is a summary only. It does not contain all information about Avidoxy DK. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.
In some countries, this medicine may only be approved for veterinary use.
In the US, Locoid (hydrocortisone topical) is a member of the drug class topical steroids and is used to treat Anal Itching, Aphthous Stomatitis - Recurrent, Atopic Dermatitis, Dermatitis, Eczema, Gingivitis, Proctitis, Pruritus, Psoriasis, Seborrheic Dermatitis, Skin Rash and Ulcerative Colitis - Active.
US matches:
UK matches:
Hydrocortisone is reported as an ingredient of Locoid in the following countries:
Hydrocortisone 17α-butyrate (a derivative of Hydrocortisone) is reported as an ingredient of Locoid in the following countries:
International Drug Name Search
Glossary
| SPC | Summary of Product Characteristics (UK) |
In some countries, this medicine may only be approved for veterinary use.
Rec.INN
P02CA06
0043210-67-9
C15-H13-N3-O2-S
299
Anthelmintic
Carbamic acid, [5-(phenylthio)-1H-benzimidazol-2-yl]-, methyl ester
International Drug Name Search
Glossary
| BAN | British Approved Name |
| IS | Inofficial Synonym |
| OS | Official Synonym |
| PH | Pharmacopoeia Name |
| Rec.INN | Recommended International Nonproprietary Name (World Health Organization) |
| USAN | United States Adopted Name |
